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09-27-2008, 10:15 AM
from http://www.thieme-connect.com/ejournals/abstract/plantamedica/doi/10.1055/s-0028-1084474
Planta Med 2008; 74
DOI: 10.1055/s-0028-1084474
Non-cannabinoid constituents from a high potency Cannabis sativa variety
MM Radwan 1, MA ElSohly 1, 4, D Slade 1, SA Ahmed 1, L Wilson 3, AT Al-Alfy 3, SA Ross 1, 2
1 National Center for Natural Products Research
2 Department of Pharmacognosy
3 Department of Pharmacology
4 Department of Pharmaceutics, School of Pharmacy, The University of Mississippi, University, MS 38677, USA
As part of our program to study the phytochemistry of high potency Cannabis sativa L. [1,2], seven new non-cannabinoid constituents were isolated, namely 5-acetoxy-6-geranyl-3-n-pentyl-1,4-benzoquinone (1), 4,5-dihydroxy-2,3,6-trimethoxy-9,10-dihydrophenanthrene (2), 4-hydroxy-2,3,6,7-tetramethoxy-9,10-dihydrophenanthrene (3), 4,7-dimethoxy-1,2,5-trihydroxyphenanthrene (4), α-cannabispiranol (5), cannflavin C (6) and β-sitosteryl-3-O-β-D-glucopyranoside-2'-O-palmitate (7). In addition, four known compounds, chrysoeriol (8), 6-prenyl-apigenin (9), cannflavin A (10) and β-acetyl cannabispiranol (11), were identified, with 8 and 9 being reported for the first time form cannabis. The antimicrobial, antileishmanial, antimalarial and anti-oxidant activities of these isolates were evaluated.
Furthermore the analgesic activity of 2, 3 and 4 was evaluated in mice using the hot-plate and tail-flick nociception models.
Planta Med 2008; 74
DOI: 10.1055/s-0028-1084474
Non-cannabinoid constituents from a high potency Cannabis sativa variety
MM Radwan 1, MA ElSohly 1, 4, D Slade 1, SA Ahmed 1, L Wilson 3, AT Al-Alfy 3, SA Ross 1, 2
1 National Center for Natural Products Research
2 Department of Pharmacognosy
3 Department of Pharmacology
4 Department of Pharmaceutics, School of Pharmacy, The University of Mississippi, University, MS 38677, USA
As part of our program to study the phytochemistry of high potency Cannabis sativa L. [1,2], seven new non-cannabinoid constituents were isolated, namely 5-acetoxy-6-geranyl-3-n-pentyl-1,4-benzoquinone (1), 4,5-dihydroxy-2,3,6-trimethoxy-9,10-dihydrophenanthrene (2), 4-hydroxy-2,3,6,7-tetramethoxy-9,10-dihydrophenanthrene (3), 4,7-dimethoxy-1,2,5-trihydroxyphenanthrene (4), α-cannabispiranol (5), cannflavin C (6) and β-sitosteryl-3-O-β-D-glucopyranoside-2'-O-palmitate (7). In addition, four known compounds, chrysoeriol (8), 6-prenyl-apigenin (9), cannflavin A (10) and β-acetyl cannabispiranol (11), were identified, with 8 and 9 being reported for the first time form cannabis. The antimicrobial, antileishmanial, antimalarial and anti-oxidant activities of these isolates were evaluated.
Furthermore the analgesic activity of 2, 3 and 4 was evaluated in mice using the hot-plate and tail-flick nociception models.