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04-01-2007, 10:37 PM
According to a study conducted at the Mayo Clinic, USA, with
52 volunteers the application of THC relaxed the large intestine.
Participants were randomly assigned to receive either a single
dose of 7.5 mg oral THC or a placebo. The effects of THC on
the colon were measured one hour after medication, during
fasting and one hour after a meal rich in calories (1000 kcal).
THC caused a significant increase in colonic compliance, a non-
significant increase of relaxation in fasting colonic tone and a
significant inhibition of colonic tone after the meal.
The authors concluded that THC relaxes the colon and reduces
the colonic motility and tone after a meal. "The potential for
CBR [cannabinoid receptors] to modulate colonic motor
function in diarrheal disease such as irritable bowel syndrome
deserves further study," they wrote.
(Source: Esfandyari T, Camilleri M, Busciglio I, Burton D,
Baxter K, Zinsmeister AR. Effects of a cannabinoid receptor
agonist on colonic motor and sensory functions in humans: a
randomized, placebo-controlled study. Am J Physiol
Gastrointest Liver Physiol 2007 Mar 29; [Electronic publication
ahead of print)
52 volunteers the application of THC relaxed the large intestine.
Participants were randomly assigned to receive either a single
dose of 7.5 mg oral THC or a placebo. The effects of THC on
the colon were measured one hour after medication, during
fasting and one hour after a meal rich in calories (1000 kcal).
THC caused a significant increase in colonic compliance, a non-
significant increase of relaxation in fasting colonic tone and a
significant inhibition of colonic tone after the meal.
The authors concluded that THC relaxes the colon and reduces
the colonic motility and tone after a meal. "The potential for
CBR [cannabinoid receptors] to modulate colonic motor
function in diarrheal disease such as irritable bowel syndrome
deserves further study," they wrote.
(Source: Esfandyari T, Camilleri M, Busciglio I, Burton D,
Baxter K, Zinsmeister AR. Effects of a cannabinoid receptor
agonist on colonic motor and sensory functions in humans: a
randomized, placebo-controlled study. Am J Physiol
Gastrointest Liver Physiol 2007 Mar 29; [Electronic publication
ahead of print)